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Dr Carmine Gentile

Pharmacist License, Bsc, Msc, PharmD, PhD

Senior Lecturer, School of Biomedical Engineering
Senior Lecturer (Hon), The University of Sydney
Sydney Medical School Foundation Fellow
Visiting Research Fellow, Harvard Medical School

Leads the Cardiovascular Regeneration Group at University of Technology Sydney

Contact

Carmine.Gentile@uts.edu.au

+61 2 9514 4502

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UTS Profile

USYD Profile

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ORCID: https://orcid.org/0000-0002-3689-4275

Dr Carmine Gentile, PharmD/PhD, FAHA, is a Lecturer within the School of Biomedical Engineering and leads the Cardiovascular Regeneration Group both at UTS and at the Kolling Institute/University of Sydney. He is a Senior Lecturer (Honorary) at the University of Sydney, a Sydney Medical School Foundation Fellow and Visiting Research Fellow at Harvard Medical School.

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He received his BSc/MSc (Pharmaceutical Chemistry and Technologies) and PharmD at the University of Pisa, Italy and his PhD in Biomedical Sciences (Cardiovascular) at the Medical University of South Carolina, Charleston, SC, USA, funded by a prestigious American Heart Association Fellowship. 

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Since 2013 Dr Gentile has worked in Australia at the Heart Research Institute, the University of Sydney and now at UTS, supported by several awards and grants, working within a multidisciplinary team with scientists, industry partners and clinicians to quickly translate his findings from bench to bedside.

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Dr Gentile is an internationally recognized expert in the field of 3D bioprinting and stem cell technologies and his more recent studies focus on novel molecular and cellular approaches to treat cardiovascular disease, including myocardial infarction and heart failure. These studies are based on the use of “mini-hearts” he developed as “bioink” for human heart tissues. In 2016, he was invited as Visiting Research Fellow at Harvard Medical School, where he worked towards novel in vitro models using mini-hearts to study human heart physiology. Following his interest for commercialisation pathways for medical devices, Dr Gentile is a Cicada Innovations Graduate (MDCTP, 2018).

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His research received media attention and featured on ABC News (2016), ABC Catalyst (2017), Sydney TEDx (2018), Daily Telegraph (2019) and 7NEWS Sydney (2020).

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ASSOCIATIONS

RESEARCH INTERESTS

  • 3D Bioprinting of Vascularized Organs and Tissues

  • Stem Cells

  • Bioinks

  • Hydrogels

  • Personalised approaches for Tissue Engineering and Regenerative Medicine

  • 3D Bioprinted in vitro Disease Models

  • 3D Bioprinted in vitro models of Cardiotoxicity and Drug testing

  • Cardiovascular Biology, Pathology and Pharmacology

  • American Association of Anatomists (AAA);
  • Australian Atherosclerosis Society (AAS);
  • American Heart Association (AHA);
  • American Physiologist Society (APS);
  • Australasian Society for Biomaterials and Tissue Engineering (ASBTE)
  • Australian Vascular Biology Society (AVBS);
  • Biophysical Society (BPS);
  • High Blood Pressure Research Council of Australia (HBPRCA);
  • International Society of Heart Research (ISHR)
  • Society for Free Radical Biology and Medicine (SFRBM);
  • Tissue Engineering and Regenerative Medicine International Society (TERMIS).

Awards

  • 2020 University of Sydney SUPRA Supervisor of the Year  (Sydney, Australia);

  • 2019 University of Sydney SUPRA Supervisor of the Year  (Sydney, Australia);

  • 2018 Sydney Medical School (University of Sydney) International Symposium on Experimental & Clinical Cardiovascular Medicine, ECR Travel Support  (Sydney, Australia);

  • 2017 University of Sydney/Sydney Medical School Foundation Fellowship (Sydney, Australia);

  • 2017 Heart Research Australia Award for Discovery Biomedical Research (Sydney, Australia);

  • 2016 Ian Potter Foundation Award (Melbourne, Australia);

  • 2016 AAS Travel Grant to visit Prof Federica del Monte at Harvard Medical School(Australia);

  • 2015 Young Investigator Award (Society for Redox Biology and Medicine Meeting, Boston, USA);

  • 2015 HRI Charles Perkins Centre Young Achiever Award (Sydney, Australia);

  • 2014 Early Career Reasearcher Travel Award (Society for Free Radical Biology and Medicine Annual Meeting, Seattle, USA);

  • 2013 First prize for outstanding oral presentation by an early career researcher(Australian Vascular Biology Society Meeting, Barossa Valley, Australia);

  • 2013-2016 Marcus Blackmore Postdoctoral Research Fellowship (Heart Research Institute, Sydney, Australia);

  • 2011-2013 American Heart Association (AHA) Pre-doctoral Fellowship (USA);

  • 2011 American Association of Anatomists (AAA) Student Travel Award (Experimental Biology Meeting, Washington DC, USA);

  • 1999-2004 PharmD Fellowship (University of Pisa, Italy).

Grants

  • American Heart Association – Predoctoral Fellowship  (11PRE7530048, Role on project: Principal Investigator). Project Title: VEGF/Akt-mediated Endothelial Nitric Oxide Synthase Phosphorylation as a Regulator of Endothelial Cell Division. 01/07/11–30/06/13

  • Heart Research Institute – Marcus Blackmores Fellowship (Role on Project: Principal Investigator). Project title: VEGF/eNOS signaling regulates the differentiation from Adipose Derived Stem Cells (ADSCs) into Cardiomyocytes (CMs) 01/03/13–31/12/16

  • The Bosch Institute – University of Sydney – Translational Grant-In-Aid (Role on Project: Co-Investigator) Project Title: Human Cardiac Tissue Spheroids (HCTSs): A Cardiotoxicity Assay 01/10/13–30/09/14

  • Ian Potter Foundation (Role on Project: Principal Investigator) Project Title: Bioprinting of Human Cardiac Patches for Heart Regeneration using Spheroids from Human Pluripotent Stem Cells. 01/06/16–31/05/19

  • University of Sydney – Kickstart Grant (Role on Project: Principal Investigator) Project Title: Bioprinted cardiac spheroids as novel models of the human heart. 01/01/17–12/01/18

  • National Health and Medical Research Council (APP1129685, Role on Project: Chief Investigator F) Project Title: A  new paradigm in redox-mediated cardiac fibrosis 01/01/17–31/12/20

  • University of Sydney/Sydney Medical School Foundation/Cardiothoracic Surgery Research Grant Scheme (Role on Project:Principal Investigator) Project Title: Bioprinting human cardiac patches for heart regeneration 01/07/17–30/01/2021

  • University of Sydney/DVC Research/Community & Industry Engagement Fund (Role on Project: Principal Investigator) Project Title: CDIP Industry & Community Engagement Fund 2017: 3D bioprinting of the human heart using patient-derived cells 01/12/17–31/12/18

  • University of Sydney/Sydney Medical School/Industry Engagement Seed Fund  (Role on Project: Principal Investigator) Project Title: 3D bioprinting of novel in vitro patient-specific human heart models for drug discovery and cardiotoxicity 01/12/17-30/11/19

  • University of Technology Sydney/FEIT Cross Faculty Collaboration Scheme (Role on Project: Co-Investigator) Project Title: Three dimensional bio-printing – establishing the future of personalised medicine approaches for women's cancers at UTS 01/07/19–30/06/20

  • Catholic Archdiocese of Sydney Grant for Adult Stem Cell Research (Principal Investigator, 2020) Project Title: Mending Broken Hearts using Stem Cells and 3D Bioprinting Technology 01/01/20–31/12/20

COLLABORATORS

Domestic

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  • University of Sydney (Sydney) – Dr Meilang Xue

  • University of Sydney (Sydney) – Prof Gemma Figtree

  • UTS (Sydney) – Dr Liang Zhao

  • UTS (Sydney) – Dr Lana McClemens

  • UTS (Sydney) – Dr Kristine McGrath

  • UTS (Sydney) – Dr Joshua Chou

  • UTS (Sydney) – Prof Peter Ralph

  • UTS (Sydney) – Prof Phil Hansbro

  • UTS (Sydney) – Dr Irina Kabakova

  • University of New South Wales (Sydney) – Prof Amanda Henry

  • University of New South Wales (Sydney) – Dr Jelena Rnjack-Kovacina

  • Garvan Institute (Sydney) – Prof Thomas Cox

  • Victor Chang Cardiac Research Centre (Australia) – Prof Michael Feneley

  • University of Newcastle (Australia) – Prof Andrew Boyle

  • Baker IDI (Australia) – Prof Xiaowei Wang

  • University of Wollongong – Prof Jeremy Crook

  • University of Wollongong – Prof Gordon Wallace

  • Inventia Life Sciences (Australia) – Dr Cameron Ferris

International​

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  • Hoffmann-LaRoche (Switzerland) - Dr Liudmila Polonchuk

  • CELLINK (Sweden) - Dr Haruka Yoshie/Tomoko Bylund

  • REGEMAT3D (Spain) – Dr José Manuel Baena

  • Pontificia Universidad Católica de Chile – A/Prof Tomás Egaña Erazo

  • Medical University of South Carolina/Harvard Medical School (USA) – Prof Federica del Monte

  • University of Copenhagen (Denmark) – Prof Michael J Davies

  • "E. Piaggio" Bioengineering Centre/University of Pisa, Pisa, (Italy) – Prof Giovanni Vozzi

  • 3D Solutions (Russia) – Prof Vladimir Mironov

  • National Research Council – Institute on Membrane Technology (Italy) – Dr Loredana de Bartolo

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